to determine by what modes or actions light produceth in our minds the phantasm of colour is not so easie.
— Isaac Newton (1672), personal correspondance to Henry Oldenburg
Divide matter into as minute parts as you will (which we are apt to imagine a sort of spiritualizing or making a thinking thing of it) vary the figure and motion of it as much as you please—a globe, cube, cone, prism, cylinder, etc., whose diameters are but 1,000,000th part of a gry, will operate not otherwise upon other bodies of proportionable bulk than those of an inch or foot diameter—and you may as rationally expect to produce sense, thought, and knowledge, by putting together, in a certain figure and motion, gross particles of matter, as by those that are the very minutest that do anywhere exist. They knock, impel, and resist one another, just as the greater do; and that is all they can do... [I]t is impossible to conceive that matter, either with or without motion, could have originally in and from itself sense, perception, and knowledge; as is evident from hence that then sense, perception, and knowledge must be a property eternally inseparable from matter and every particle of it.
— John Locke (1689), An essay concerning human understanding
Moreover, it must be confessed that perception and that which depends upon it are inexplicable on mechanical grounds, that is to say, by means of figures and motions. And supposing there were a machine, so constructed as to think, feel, and have perception, it might be conceived as increased in size, while keeping the same proportions, so that one might go into it as into a mill. That being so, we should, on examining its interior, find only parts which work one upon another, and never anything by which to explain a perception.
—Gottfried Leibniz (1714)
Now I am far from pretending that it may not be capable of proof, or that it is not an important addition to our knowledge if proved, that certain motions in the particles of bodies are the conditions of the production of heat or light; that certain assignable physical modifications of the nerves may be the conditions not only of our sensations or emotions, but even of our thoughts; that certain mechanical and chemical conditions may, in the order of nature, be sufficient to determine to action the physiological laws of life. All I insist upon, in common with every thinker who entertains any clear idea of the logic of science, is, that it shall not be supposed that by proving these things one step would be made towards a real explanation of heat, light, or sensation; or that the generic peculiarity of those phenomena can be in the least degree evaded by any such discoveries, however well established. Let it be shown, for instance, that the most complex series of physical causes and effects succeed one another in the eye and in the brain to produce a sensation of colour; rays falling on the eye, refracted, converging, crossing one another, making an inverted image on the retina, and after this a motion—let it be a vibration, or a rush of nervous fluid, or whatever else you are pleased to suppose, along the optic nerve—a propagation of this motion to the brain itself, and as many more different motions as you choose; still, at the end of these motions, there is something which is not motion, there is a feeling or sensation of colour. Whatever number of motions we may be able to interpolate, and whether they be real or imaginary, we shall still find, at the end of the series, a motion antecedent and a colour consequent. The mode in which any one of the motions produces the next, may possibly be susceptible of explanation by some general law of motion: but the mode in which the last motion produces the sensation of colour, cannot be explained by any law of motion; it is the law of colour: which is, and must always remain, a peculiar thing. Where our consciousness recognises between two phenomena an inherent distinction; where we are sensible of a difference which is not merely of degree, and feel that no adding one of the phenomena to itself would produce the other; any theory which attempts to bring either under the laws of the other must be false; though a theory which merely treats the one as a cause or condition of the other, may possibly be true.
— John Stuart Mill, A System Of Logic (1843), Book V, Chapter V, section 3
But what consciousness is, we know not; and how it is that anything so remarkable as a state of consciousness comes about as the result of irritating nervous tissue, is just as unaccountable as the appearance of the Djin when Aladdin rubbed his lamp in the story, or as any other ultimate fact of nature.
— Thomas Henry Huxley (1868)