The 2006 Cal Poly Mustangs football team represented California Polytechnic State University during the 2006 NCAA Division I FCS football season.
Cal Poly competed in the Great West Football Conference (GWFC). The Mustangs were led by sixth-year head coach Rich Ellerson and played home games at Mustang Stadium in San Luis Obispo, California. The team finished the season with a record of seven wins and four losses (7–4, 2–2 GWFC). The Mustangs outscored their opponents 248–162 for the season.
== Schedule ==
== Team players in the NFL ==
The following Cal Poly Mustang players were selected in the 2007 NFL Draft.
== Notes ==
== References ==