[<< wikipedia] Streptazolin
Streptazolin is an antibiotic and antifungal substance isolated in 1981 from Streptomyces viridochromogenes.Because of its polymerisation tendency, it is not suitable for therapeutic use. 1,4-reduction of the conjugated diene gives dihydrostreptazolin which is stable, but has very limited antimicrobial properties.The first total synthesis of (racemic) streptazolin was achieved in 1985 with the aid of a modified Ferrier rearrangement.


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