[<< wikibooks] Radiation Oncology/Rectum/Review
Rectal Cancer Review

Surgical margin
R0 typically defined as >1 mm
Prognostic impact on LR and OS
Neoadjuvant chemo-RT
Superior over adjuvant chemo-RT: German Rectal Trial
Superior over neoadjuvant RT alone: EORTC 22921 and FFCD 9203
No difference in OS, 5-year ~65%
Significant benefit for LR 16-17% -> 8-9%
R0 ~90%; ypCR 15-20%