[<< wikibooks] Radiation Oncology/Sarcoma/Hemangioendothelioma

Rare tumor
Intermediate-grade malignant tumors, clinically behaving between benign hemangioma and malignant angiosarcoma. Some have rather benign course while others show much more malignant progression
Typically occur in adults with roughly equal sex distribution
Most common location is soft tissues, but have been described essentially anywhere in the body
Symptoms depend upon location of the primary tumor
Most common histologic type is epithelioid hmangioendothelioma (EHE)
For isolated tumors, curative resection with negative margin should be performed
Role of adjuvant RT is unclear, but is often considered
Most common metastatic sites are lungs, liver, lymph nodes and bone
Effectiveness of chemotherapy is unclear
Most studies are small single institution series